Cancer Help Guide

Adrenocortical carcinoma · NCT05237934

Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)

Status
RECRUITING (ClinicalTrials.gov)
Phase
observational
Sponsor
National Cancer Institute (NCI)
Registry records
CTGOV NCT05237934 (RECRUITING)
Registry last updated 2026-11-02

Eligibility, line by line

VerdictIn plain words (machine summary)Registry text, verbatimIf unmet
inclusion
inclusion · age sex · confidence 0.97
Age >= 18 years old"Age \>= 18 years old"
inclusion
inclusion · consent · confidence 0.30
The ability of the participant to understand and the willingness to sign a written consent document."The ability of the participant to understand and the willingness to sign a written consent document."
inclusion
inclusion · condition · confidence 0.90
Histological or cytological confirmation of NENs or adrenocortical cancer"histological or cytological confirmation of NENs or adrenocortical cancer"
inclusion
inclusion · biomarker · confidence 0.85
Biochemical evidence of neuroendocrine tumor (serum/urinary) based on elevated levels of chromogranin A, pancreatic polypeptide, neuron-specific enolase, vasoactive intestinal polypeptide, serotonin (urinary 5-HIAA), gastrin, somatostatin, catecholamines, metanephrines, calcitonin, fasting insulin, C-peptide (proinsulin), glucagon, anterior pituitary hormones"biochemical evidence of neuroendocrine tumor (serum/urinary) based on elevated levels of chromogranin A, pancreatic polypeptide, neuron-specific enolase, vasoactive intestinal polypeptide, serotonin (urinary 5-hydroxyindoleacetic acid (5-HIAA)), gastrin, somatostatin, catecholamines, metanephrines, calcitonin, fasting insulin, Cpeptide (proinsulin), glucagon, anterior pituitary hormones"
inclusion
inclusion · condition · confidence 0.85
Suspicion of NEN (from any site/origin) on axial imaging (CT/MRI/FDG PET/68Ga-Dotatate scan)"Suspicion of NEN (from any site/origin) on axial imaging (computed tomography (CT)/ magnetic resonance imaging (MRI) / fluorodeoxyglucose (FDG) positron emission tomography (PET) / 68Ga-Dotatate scan"
inclusion
inclusion · biomarker · confidence 0.90
A germline genetic variant that predisposes to NETs including ACC."a germline genetic variant that predisposes to NETs including ACC."

Criteria extracted by claude-sonnet-5-5; 0 extracted quotes rejected for not matching the registry text.

Full eligibility text as the registry publishes it
* INCLUSION CRITERIA:
* Age \>= 18 years old
* The ability of the participant to understand and the willingness to sign a written consent document.
* Participants with the documentation of:

  * histological or cytological confirmation of NENs or adrenocortical cancer

OR

--biochemical evidence of neuroendocrine tumor (serum/urinary) based on elevated levels of chromogranin A, pancreatic polypeptide, neuron-specific enolase, vasoactive intestinal polypeptide, serotonin (urinary 5-hydroxyindoleacetic acid (5-HIAA)), gastrin, somatostatin, catecholamines, metanephrines, calcitonin, fasting insulin, Cpeptide (proinsulin), glucagon, anterior pituitary hormones

OR

--Suspicion of NEN (from any site/origin) on axial imaging (computed tomography (CT)/ magnetic resonance imaging (MRI) / fluorodeoxyglucose (FDG) positron emission tomography (PET) / 68Ga-Dotatate scan

OR

--a germline genetic variant that predisposes to NETs including ACC.

EXCLUSION CRITERIA:

None

Routes in: how this trial is reached and paid for

  • NIH Clinical Center: care at no cost, travel supported

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    Care 0; transatlantic flight at your own cost, then supported

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Sites (1)

United States

  • National Institutes of Health Clinical Center, Bethesda